Syria in state of war, says Bashar al-Assad
Addressing his new cabinet, Mr Assad said that all efforts had to be directed towards winning the war.
Hours later, gunmen attacked pro-government Ikhbariya TV channel, killing three people, state media said.
The UN's human rights council is due to hear a report on Syria, including its findings on the Houla massacre.
A commission of inquiry has been investigating human rights violations in the conflict and its chairman, Paulo Pinheiro, was able to enter the country for the first time on Monday.
Earlier this month, the Geneva-based UN council called on the commission to find out who carried out last month's killings in Houla in which 108 people died.
'Winning this war'
"We live in a real state of war from all angles," President Assad told members of the cabinet who were sworn in on Tuesday.
"When we are in a war, all policies and all sides and all sectors need to be directed at winning this war."
He criticised countries that have been calling for him to stand down, saying that the West "takes and never gives and this has been proven at every stage".
President Assad has promised reforms but the opposition says they do not go far enough
He added: "We want good relations with all countries but we must know where our interests lie."